TBC1D14 Antibody, FITC conjugated

Code CSB-PA889187LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TBC1D14 Polyclonal antibody
Uniprot No.
Target Names
TBC1D14
Alternative Names
FLJ32400 antibody; KIAA1322 antibody; TBC1 domain family member 14 antibody; TBC14_HUMAN antibody; Tbc1d14 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TBC1 domain family member 14 protein (136-435AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.
Gene References into Functions
  1. TRAPPC8 modulates autophagy and secretory trafficking and is required for TBC1D14 to bind TRAPPIII. PMID: 26711178
  2. TBC1D14 binds activated Rab11 but is not a GAP for Rab11, and loss of Rab11 prevents TBC1D14-induced tubulation of recycling endosomes. PMID: 22613832
  3. crystal structures of the first two mammalian TBCs, human TBC1 family members 22A (TBC1D22A) and 14 (TBC1D14) PMID: 18186464
Subcellular Location
Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Note=After amino acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling between the Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation.
Database Links

HGNC: 29246

OMIM: 614855

KEGG: hsa:57533

STRING: 9606.ENSP00000386921

UniGene: Hs.518611

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