TBC1D4 Antibody

Code CSB-PA023218LA01HU
Size US$166
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  • Immunohistochemistry analysis of human adrenal gland tissue using CSB-PA023218LA01HU at dilution of 1:100

  • Immunocytochemistry analysis of human kidney tissue using CSB-PA023218LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA023218LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TBC1D4 Polyclonal antibody
Uniprot No.
Target Names
TBC1D4
Alternative Names
Acrg embryonic lethality (mouse) minimal region ortholog antibody; Acrg embryonic lethality minimal region ortholog antibody; Acrg embryonic lethality mouse minimal region ortholog antibody; Akt substrate of 160 kDa antibody; AS 160 antibody; AS160 antibody; BUB2 antibody; CDC16 antibody; KIAA0603 antibody; NIDDM5 antibody; TBC (Tre 2 BUB2 CDC16) domain containing protein antibody; TBC Tre 2 BUB2 CDC16 domain containing protein antibody; TBC1 D4 antibody; TBC1 domain family member 4 antibody; Tbc1d4 antibody; TBCD4_HUMAN antibody; Tre-2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TBC1 domain family member 4 protein (1-94AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TBC1D4 Antibody (Product code: CSB-PA023218LA01HU) is Non-conjugated. For TBC1D4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA023218LB01HU TBC1D4 Antibody, HRP conjugated ELISA
FITC CSB-PA023218LC01HU TBC1D4 Antibody, FITC conjugated
Biotin CSB-PA023218LD01HU TBC1D4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Gene References into Functions
  1. C-terminal region (CTR) region is largely alpha-helical and mediates TBC1D4 RabGAP dimerization PMID: 28545963
  2. Disruption of TBC1D4 is common among North American Inuit, resulting in exclusively elevated postprandial glucose. This leads to underdiagnosis of type 2 diabetes, unless an OGTT is performed. PMID: 27561922
  3. AS160 regulates glucose-independent eukaryotic cell proliferation through p21-dependent control of the cell cycle. PMID: 27152871
  4. AS160 and TBC1D1 phosphorylations were evident 30 min after exercise. PMID: 24876356
  5. homozygous carriers of a nonsense p.Arg684Ter variant have markedly higher concentrations of plasma glucose and serum insulin 2 hours after an oral glucose load compared with individuals with other genotypes PMID: 25043022
  6. Findings suggest that a dampening of insulin-induced phosphorylation of AS160 on specific sites in skeletal muscle contributes to the insulin resistance evident in a sedentary aging population PMID: 23801578
  7. insulin resistance in muscles from healthy individuals is associated with suppression of site-specific phosphorylation of AS160 PMID: 22028408
  8. AS160 interacts with the large cytoplasmic NP domain of the alpha-subunit of the Na(+),K(+)-ATPase. AMP-stimulated protein kinase (AMPK) and AS160 participate in a common pathway to modulate the cell surface expression of the Na(+),K(+)-ATPase. PMID: 20943949
  9. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. PMID: 21454505
  10. AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane PMID: 21454690
  11. Impaired insulin-induced site-specific TBC1D4 phosphorylation may contribute to skeletal muscle insulin resistance in type 2 diabetes. PMID: 20938636
  12. results show AS160 phosphorylation level is frequently increased in breast cancer; results implicate a possible role of AS160 in breast tumorigenesis and suggest that p-AS160 might be useful as a marker and a potential novel treatment target PMID: 20574165
  13. WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex PMID: 20937822
  14. S711 is a novel TBC1D4 phosphorylation site regulated by AMPK in skeletal muscle. PMID: 19923418
  15. KIAA0603 is likely to be a Rab GAP that participates in the regulation of activated T cells in atopic dermatitis PMID: 15304337
  16. In this study, we determined the expression of and in vivo insulin action on AS160 in skeletal muscle of normal and type 2 diabetic patients. PMID: 15919790
  17. results indicate that AS160 is a Rab GAP, and suggest novel Rabs that may participate in GLUT4 translocation PMID: 15971998
  18. AS160 is phosphorylated in a time-dependent manner during moderate-intensity exercise. PMID: 17077344
  19. Regulation of AS160 and interaction with 14-3-3 in skeletal muscle are influenced by resistance exercise and insulin but do not fully explain the effect of resistance exercise on whole-body insulin action. PMID: 17369524
  20. Effects of endurance exercise training on insulin signaling and AS160 in human skeletal muscle PMID: 17513702
  21. AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. PMID: 17617058
  22. Impaired insulin signaling through Akt and AS160 in part explains insulin resistance at the molecular level in skeletal muscle in polycystic ovary syndrome. PMID: 17977950
  23. AS160, previously recognized as a key player in insulin signaling in skeletal muscle and adipose tissue, is also a major effector of protein kinase B/Akt signaling in the beta-cell. PMID: 18276765
  24. The transcript variant 2 of AS160 in contrast to full-length AS160 is a novel regulator of glucose transport that positively influences glucose-uptake rates. PMID: 18771725
  25. muscle TBC1D4 phosphorylation across the leg is increased during recovery following resistance exercise PMID: 18845784
  26. Specific phosphorylation of TBC1D4 in human skeletal muscle in response to physiological exercise-induced hyperinsulinemia. PMID: 19252894
  27. Prematurely truncated TBC1D4 protein tended to increase basal cell membrane GLUT4 levels (P = 0.053) and significantly reduced insulin-stimulated GLUT4 cell membrane translocation (P < 0.05). PMID: 19470471

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Involvement in disease
Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5)
Subcellular Location
Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Tissue Specificity
Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland,
Database Links

HGNC: 19165

OMIM: 612465

KEGG: hsa:9882

STRING: 9606.ENSP00000366863

UniGene: Hs.210891

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