TBC1D7 Antibody

Code CSB-PA873720LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA873720LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA873720LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA873720LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TBC1D7 Polyclonal antibody
Uniprot No. Q9P0N9
Target Names TBC1D7
Alternative Names TBC1D7 antibody; TBC7 antibody; HSPC239 antibody; TBC1 domain family member 7 antibody; Cell migration-inducing protein 23 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human TBC1 domain family member 7 protein (1-293AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Involvement in disease Macrocephaly/megalencephaly syndrome, autosomal recessive (MGCPH)
Subcellular Location Cytoplasmic vesicle
Tissue Specificity Highly expressed in heart, and slightly in kidney, liver and placenta.
Database Links

HGNC: 21066

OMIM: 248000

KEGG: hsa:107080638

STRING: 9606.ENSP00000348813

UniGene: Hs.484678

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