TERT Antibody, HRP conjugated

Datasheet

Code	CSB-PA023391LB01DO
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Canis lupus familiaris (Dog) (Canis familiaris) TERT Polyclonal antibody

Uniprot No.

Q6A548

Target Names

TERT

Alternative Names

TERT antibody; Telomerase reverse transcriptase antibody; EC 2.7.7.49 antibody; Telomerase catalytic subunit antibody

Raised in

Rabbit

Species Reactivity

Dog

Immunogen

Recombinant Dog Telomerase reverse transcriptase protein (1-308AA)

Immunogen Species

Canis lupus familiaris (Dog) (Canis familiaris)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Gene References into Functions

This study evaluated the relationship between polymorphisms of Telomerase Reverse Transcriptase and the longevity and cancer susceptibility of 4 dog breeds. PMID: 24423165
This study reports that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. PMID: 21062413
Dog TERT shows the highest level of sequence similarity to the human TERT protein, supporting the dog as a model system for telomerase-based studies. PMID: 15225880
Localization of catalytic subunit of telomerase reverse transcriptase in normal lens epithelial cells(LEC)corresponded with LEC's regional functions. (Catalytic subunit of telomerase reverse transcriptase) PMID: 17093391
A higher expression of TERT was noted in canine and feline meningionas. PMID: 17519562
These findings suggest that telomerase may be a valuable target for canine osteosarcoma (OSA) therapy, and that telomerase status does not appear to be a prognostic factor in canine OSA. PMID: 18761602
DNA sequencing revealed two insertions (175 and 28 bp long) and two deletions (17 and 32 bp long), which were encountered in different combinations and gave rise to five different transcripts. PMID: 18836773
TERT interacted with ERalpha via the estrogen response element (ERE) in cataractous lens epithelial cells (LEC) but not in normal LEC. PMID: 19936027

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Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body.

Protein Families

Reverse transcriptase family, Telomerase subfamily

Database Links

KEGG: cfa:403412

STRING: 9615.ENSCAFP00000015805

UniGene: Cfa.114

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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