TFAP2E Antibody, FITC conjugated

Code CSB-PA761516LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TFAP2E Polyclonal antibody
Uniprot No. Q6VUC0
Target Names TFAP2E
Alternative Names TFAP2ETranscription factor AP-2-epsilon antibody; AP2-epsilon antibody; Activating enhancer-binding protein 2-epsilon antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Transcription factor AP-2-epsilon protein (66-175AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).
Gene References into Functions
  1. Results showed that lower expression levels of TFAP2E are significantly associated with a shorter survival of patients with neuroblastoma indicating that TFAP2E acts as a tumor suppressor of neuroblastoma. PMID: 28260105
  2. Hypermethylation of TFAP2E was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in patients with gastric cancer. PMID: 25810491
  3. AP-2E was frequently hypermethylated in tumors from patients with colorectal cancer PMID: 24996990
  4. AP-2epsilon indirectly interacts with the core promoter of COL2A1 and subsequently inhibits its transcriptional activity, thus modulating cartilage development. PMID: 23331625
  5. TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. PMID: 22216841
  6. These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e, promotes melanophore differentiation in parallel with Mitf by an effector other than Kit. PMID: 20862309

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Subcellular Location Nucleus
Protein Families AP-2 family
Tissue Specificity Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.
Database Links

HGNC: 30774

OMIM: 614428

KEGG: hsa:339488

STRING: 9606.ENSP00000362332

UniGene: Hs.567844

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