||Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity).
|Gene References into Functions
- Results showed that lower expression levels of TFAP2E are significantly associated with a shorter survival of patients with neuroblastoma indicating that TFAP2E acts as a tumor suppressor of neuroblastoma. PMID: 28260105
- Hypermethylation of TFAP2E was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in patients with gastric cancer. PMID: 25810491
- AP-2E was frequently hypermethylated in tumors from patients with colorectal cancer PMID: 24996990
- AP-2epsilon indirectly interacts with the core promoter of COL2A1 and subsequently inhibits its transcriptional activity, thus modulating cartilage development. PMID: 23331625
- TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. PMID: 22216841
- These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e, promotes melanophore differentiation in parallel with Mitf by an effector other than Kit. PMID: 20862309
||Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.