TGFBRAP1 Antibody, FITC conjugated

Code CSB-PA819888LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TGFBRAP1 Polyclonal antibody
Uniprot No.
Target Names
TGFBRAP1
Alternative Names
TGFBRAP1 antibody; Transforming growth factor-beta receptor-associated protein 1 antibody; TGF-beta receptor-associated protein 1 antibody; TRAP-1 antibody; TRAP1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transforming growth factor-beta receptor-associated protein 1 protein (401-600AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo.
Gene References into Functions
  1. Vps3 and Vps8 are required for recycling of beta1 integrins. PMID: 29476049
  2. MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. PMID: 27301951
  3. the association of rs2679860 polymorphisms of TGFBRAP1 and DBP variation as well as plasma levels of TGF-beta1 PMID: 25856002
  4. In the absence of Langerhans cells (LC), contact hypersensitivity (CHS) reactions in langerin-positive dendritic cell-specific TGF-betaR1-deficient mice are diminished, providing further evidence against a regulatory role for LC in CHS. PMID: 21998450
Subcellular Location
Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
Protein Families
TRAP1 family
Database Links

HGNC: 16836

OMIM: 606237

KEGG: hsa:9392

STRING: 9606.ENSP00000258449

UniGene: Hs.446350

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