THAP11 Antibody

1. A transcriptional repressor network including THAP domain containing 11 protein (THAP11) was identified and negatively regulates endogenous PARKIN abundance. PMID: 29269392
2. We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 and THAP11 are essential for normal brain development and neural precursor differentiation. PMID: 28449119
3. the crystal structure of the C-ter region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features. PMID: 26975212
4. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 PMID: 27576892
5. THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy. PMID: 25437553
6. that THAP11 reversibly regulated erythroid and megakaryocytic differentiation. PMID: 24637716
7. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. PMID: 23539139
8. In HCC patients, the expression of THAP11 mRNA significantly correlated with PCBP1 mRNA expression. Our results suggest a novel role of THAP11 in CD44 alternative splicing and hepatoma invasion PMID: 22673507
9. identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer PMID: 22371484
10. the induced THAP11 might be one of transcriptional regulators of c-Myc expression in CML cell. PMID: 21400515
11. Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc. PMID: 19008924

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HGNC: 23194

OMIM: 609119

KEGG: hsa:57215

STRING: 9606.ENSP00000304689

UniGene: Hs.632200