TIFA Antibody

Code CSB-PA839301LA01HU
Size US$166
Order now
The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TIFA Polyclonal antibody
Uniprot No.
Target Names
TIFA
Alternative Names
Putative MAPK activating protein PM14 antibody; Putative MAPK-activating protein PM14 antibody; Putative NF kappa B activating protein 20 antibody; Putative NF-kappa-B-activating protein 20 antibody; T2BP antibody; TIFA antibody; TIFA_HUMAN antibody; TRAF interacting protein with FHA domain containing protein A antibody; TRAF-interacting protein with FHA domain-containing protein A antibody; TRAF2 binding protein antibody; TRAF2-binding protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TRAF-interacting protein with FHA domain-containing protein A protein (1-184AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TIFA Antibody (Product code: CSB-PA839301LA01HU) is Non-conjugated. For TIFA Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA839301LB01HU TIFA Antibody, HRP conjugated ELISA
FITC CSB-PA839301LC01HU TIFA Antibody, FITC conjugated
Biotin CSB-PA839301LD01HU TIFA Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Customer Reviews and Q&A

 Customer Reviews
Average Rating:
5.0 - 1 reviews

Submit a Review here

Applications : Western blot analysis

Sample type: cell

Review: Loss of Smac upon Hp-infection (Fig.S7-H) was unaltered in TIFA-deficient cells.

By Anonymous

Target Background

Function
Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling.
Gene References into Functions
  1. TIFA may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins. PMID: 29975933
  2. TIFA is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 inflammasome via augmenting signals 1 and 2 PMID: 27965388
  3. study revealed that host TIFA and H. pylori-derived heptose-1,7-bisphosphate are critical effectors of innate immune signaling that account for much of the inflammatory response to H. pylori in gastric epithelial cells PMID: 28811347
  4. These results define TIFA as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth. PMID: 28514661
  5. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein TIFA PMID: 28069801
  6. This study reports the crystal structures of TIFA (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15). PMID: 26389808
  7. an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate. PMID: 26068852
  8. identify a novel threonine phosphorylation site on TIFA and show that this phosphorylated threonine binds with the FHA domain of TIFA, leading to TIFA oligomerization and TIFA-mediated NF-kappaB activation PMID: 22566686
  9. TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism PMID: 15492226

Show More

Hide All

Subcellular Location
Cytoplasm.
Database Links

HGNC: 19075

OMIM: 609028

KEGG: hsa:92610

STRING: 9606.ENSP00000354911

UniGene: Hs.310640

CUSABIO guaranteed quality
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*