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TIPRL Antibody, FITC conjugated

Datasheet
Code CSB-PA023569LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TIPRL Polyclonal antibody
Uniprot No.
O75663
Target Names
TIPRL
Alternative Names
1810011K17Rik antibody; dJ69E11.3 antibody; MGC3794 antibody; Putative MAPK activating protein PM10 antibody; Putative MAPK-activating protein PM10 antibody; RP1-69E11.1 antibody; Tip antibody; TIP41 antibody; TIP41-like protein antibody; tiprl antibody; TIPRL_HUMAN antibody; TOR signaling pathway regulator antibody; TOR Signaling Pathway Regulator like antibody; Type 2A-interacting protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TIP41-like protein (1-178AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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TIPRL Proteins

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Target Background

Function
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Gene References into Functions
  1. overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation PMID: 26717153
  2. Unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac. PMID: 23892082
  3. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
  4. TIPRL is highly up-regulated in human HCC samples and cell lines, compared with noncancerous liver tissues. PMID: 22841785
  5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
  6. Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610

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Subcellular Location
Cytoplasm.
Protein Families
TIP41 family
Database Links

HGNC: 30231

OMIM: 611807

KEGG: hsa:261726

STRING: 9606.ENSP00000356807

UniGene: Hs.209431

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