TMOD1 Antibody

Datasheet

Code	CSB-PA023909ESR2HU
Size	US$166
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Image	Western blot All lanes: TMOD1 antibody at 1.85μg/ml Lane 1: Mouse brain tissue Lane 2: Mouse lung tissue Lane 3: Hela whole cell lysate Lane 4: K562 whole cell lysate Lane 5: A549 whole cell lysate Lane 6: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 41, 27 kDa Observed band size: 41 kDa Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA023909ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA023909ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TMOD1 Polyclonal antibody

Uniprot No.

P28289

Target Names

TMOD1

Alternative Names

D9S57E antibody; E Tmod antibody; E tropomodulin antibody; E-Tmod antibody; Erythrocyte tropomodulin antibody; ETMOD antibody; MGC124125 antibody; MGC124126 antibody; OTTHUMP00000021743 antibody; TMOD antibody; Tmod1 antibody; TMOD1 protein antibody; TMOD1_HUMAN antibody; Tropomodulin 1 antibody; Tropomodulin-1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Tropomodulin-1 protein (1-359AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The immunization of rabbits with the recombinant human TMOD1 protein (1-359AA) and final purification from rabbit antiserum by antigen affinity purification causes the creation of the anti-TMOD1 antibody. This TMOD1 antibody is a polyclonal antibody and occurs as an unconjugated IgG. It is reactive with human and mouse TMOD1 protein, a tropomyosin (TM)-binding protein that exerts an important role in controlling the organization of actin filaments. And this anti-TMOD1 antibody has been validated for use in ELISA, WB, and IHC applications.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

Gene References into Functions

Tmod1 function in mouse and human erythroblasts, was investigated. PMID: 28729432
The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies . PMID: 26873245
Study highlighted a novel TMOD1-mediated link between NF-kappaB activation and MMP13 induction, which accounts in part for the NF-kappaB-dependent malignant phenotype of TNBC. PMID: 25398440
Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization. PMID: 24922351
The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament. PMID: 25061212
Tropomyosin requires an intact N-terminal coiled coil to interact with this protein PMID: 11964245
levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway PMID: 15095301
The N-terminal "KRK ring" may participate in balancing electrostatic force with hydrophobic interaction in dimerization of TM and its binding to E-Tmod. PMID: 16297372
study identifies several amino acid residues on Tmod-1 that are important for its interaction with TM5 (a nonmuscle TM isoform) PMID: 16434395

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Subcellular Location

Cytoplasm, cytoskeleton.

Protein Families

Tropomodulin family

Tissue Specificity

Highly expressed in the erythrocyte, heart and skeletal muscle.

Database Links

HGNC: 11871

OMIM: 190930

KEGG: hsa:7111

STRING: 9606.ENSP00000259365

UniGene: Hs.404289

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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