TNKS1BP1 Antibody

Datasheet

Code	CSB-PA871634LA01HU
Size	US$166
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Image	IHC image of CSB-PA871634LA01HU diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA871634LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of Hela cells with CSB-PA871634LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TNKS1BP1 Polyclonal antibody

Uniprot No.

Q9C0C2

Target Names

TNKS1BP1

Alternative Names

182 kDa tankyrase 1 binding protein antibody; 182 kDa tankyrase-1-binding protein antibody; FLJ45975 antibody; KIAA1741 antibody; TAB182 antibody; Tankyrase 1 binding protein 1 182 kDa antibody; Tankyrase 1 binding protein 1 antibody; Tankyrase 1 binding protein of 182 kDa antibody; TB182_HUMAN antibody; Tnks1bp1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human 182 kDa tankyrase-1-binding protein (271-375AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TNKS1BP1 Antibody (Product code: CSB-PA871634LA01HU) is Non-conjugated. For TNKS1BP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA871634LB01HU	TNKS1BP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA871634LC01HU	TNKS1BP1 Antibody, FITC conjugated
Biotin	CSB-PA871634LD01HU	TNKS1BP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Gene References into Functions

Results found that TNKS1BP1 was upregulated in human lung adenocarcinoma tissues, and regulates genome stability, mainly through affecting the homologous recombination pathway of DNA double-strand breaks. These results indicate that overexpression of TNKS1BP1 might affect the outcomes of lung cancer patients to chemotherapy and radiotherapy. PMID: 28058814
In clinical samples of pancreatic cancer, TNKS1BP1 expression was reduced in invasive regions. We propose that the tankyrase-TNKS1BP1 axis constitutes a posttranslational modulator of cell invasion whose aberration promotes cancer malignancy PMID: 28202517
TNKS1BP1 has a role in DNA double-strand break repair though DNA-PKcs autophosphorylation which is dependent on PARP-1 PMID: 25749521
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). PMID: 11854288
Identification of a tankyrase-binding motif in this protein. PMID: 12080061
Data show that tankyrase 1 inhibition in human cancer cells enhances telomere shortening by a telomerase inhibitor and hastens cell death. PMID: 15652747
We also demonstrate a requirement for tankyrase-1 in the assembly of bipolar spindles, and identify the spindle-pole protein NuMA as a substrate for covalent modification by tankyrase-1. PMID: 16244666
TNKS-1 mRNA in urine sediment from patients with bladder TCC correlated with tumor stage, and higher preoperative levels were associated with increased risk of early recurrence. PMID: 17617028

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Subcellular Location

Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.

Tissue Specificity

Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.

Database Links

HGNC: 19081

OMIM: 607104

KEGG: hsa:85456

STRING: 9606.ENSP00000350990

UniGene: Hs.530730

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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