TNRC6B Antibody

Code CSB-PA892489LA01HU
Size US$166
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Image
  • Immunofluorescence staining of A549 cells with CSB-PA892489LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TNRC6B Polyclonal antibody
Uniprot No.
Target Names
TNRC6B
Alternative Names
TNRC6B antibody; KIAA1093 antibody; Trinucleotide repeat-containing gene 6B protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Trinucleotide repeat-containing gene 6B protein (639-779AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TNRC6B Antibody (Product code: CSB-PA892489LA01HU) is Non-conjugated. For TNRC6B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA892489LB01HU TNRC6B Antibody, HRP conjugated ELISA
FITC CSB-PA892489LC01HU TNRC6B Antibody, FITC conjugated
Biotin CSB-PA892489LD01HU TNRC6B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Gene References into Functions
  1. The rs12484776 significantly contributes to uterine myoma risk among Saudi women, both in single and also in synergistic cooperation with rs2280543, rs7913069, and rs1056836 markers. PMID: 27987337
  2. single nucleotide polymorphisms in the TNRC6B gene is associated with uterine fibroid. PMID: 23604678
  3. Trinucleotide repeat containing 6B (TNRC6B) rs12484776 associated with uterine fibroid volume in european americans. PMID: 23892540
  4. Our findings indicate that TNRC6B, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768
Subcellular Location
Cytoplasm, P-body.
Protein Families
GW182 family
Database Links

HGNC: 29190

OMIM: 610740

KEGG: hsa:23112

STRING: 9606.ENSP00000401946

UniGene: Hs.372082

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