TNRC6B Antibody

Datasheet

Code	CSB-PA892489LA01HU
Size	US$166
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Image	Immunofluorescence staining of A549 cells with CSB-PA892489LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TNRC6B Polyclonal antibody

Uniprot No.

Q9UPQ9

Target Names

TNRC6B

Alternative Names

TNRC6B antibody; KIAA1093 antibody; Trinucleotide repeat-containing gene 6B protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Trinucleotide repeat-containing gene 6B protein (639-779AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TNRC6B Antibody (Product code: CSB-PA892489LA01HU) is Non-conjugated. For TNRC6B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA892489LB01HU	TNRC6B Antibody, HRP conjugated	ELISA
FITC	CSB-PA892489LC01HU	TNRC6B Antibody, FITC conjugated
Biotin	CSB-PA892489LD01HU	TNRC6B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Gene References into Functions

The rs12484776 significantly contributes to uterine myoma risk among Saudi women, both in single and also in synergistic cooperation with rs2280543, rs7913069, and rs1056836 markers. PMID: 27987337
single nucleotide polymorphisms in the TNRC6B gene is associated with uterine fibroid. PMID: 23604678
Trinucleotide repeat containing 6B (TNRC6B) rs12484776 associated with uterine fibroid volume in european americans. PMID: 23892540
Our findings indicate that TNRC6B, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768

Subcellular Location

Cytoplasm, P-body.

Protein Families

GW182 family

Database Links

HGNC: 29190

OMIM: 610740

KEGG: hsa:23112

STRING: 9606.ENSP00000401946

UniGene: Hs.372082

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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