TNS4 Antibody

1. CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. PMID: 29985912
2. Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. PMID: 29102927
3. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
4. Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3. PMID: 26852686
5. Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma PMID: 26035355
6. Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3. PMID: 25439778
7. Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients. PMID: 24244691
8. Up-regulated cten modulates cell migration induced by FGF2. PMID: 23625726
9. Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. PMID: 24814316
10. CTEN regulates EGFR protein levels through a posttranslational mechanism. PMID: 23774213
11. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. PMID: 23500447
12. Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility. PMID: 22750970
13. conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility PMID: 21698197
14. Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis. PMID: 21339732
15. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma. PMID: 20390342
16. Increased cten mRNA expression was correlated with tumor progression in lung cancers PMID: 12711115
17. Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma. PMID: 15001839
18. These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. PMID: 17190795
19. Expression of CTEN correlates with high tumor grade and metastasis to lymph nodes, suggesting that CTEN may contribute to tumor invasiveness. PMID: 17765673
20. TNS4 mRNA expression was significantly higher in gastric cancer. PMID: 18612693
21. Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers. PMID: 19487278
22. CTEN plays an important role in paclitaxel sensitivity, and CTEN expression level may be a prognostic predictive factor for prostate cancer patients. PMID: 19725034

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HGNC: 24352

OMIM: 608385

KEGG: hsa:84951

STRING: 9606.ENSP00000254051

UniGene: Hs.438292