TOM1 Antibody, Biotin conjugated

1. This study demonstrated that Tom1 is localized in dystrophic neurites of brain in patient with Alzheimer's disease. PMID: 27206884
2. Tom1 modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism. PMID: 26320582
3. candidate multiple myeloma risk locus PMID: 26007630
4. phosphatidylinositol 5-monophosphate (PI5P) enrichment in signaling endosomes prevents endosomal maturation through the recruitment of TOM1, and point to a new function of PI5P in regulating discrete maturation steps in the endosomal system. PMID: 25588840
5. It was shown that that myosin VI, in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI binding partner on endosomes. PMID: 23023224
6. TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis lung. PMID: 20083669
7. a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin PMID: 14563850
8. marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
9. Tollip and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins PMID: 15047686
10. The results suggest that TOM1 is an important molecule for membrane recruitment of clathrin, and that endofin is able to exploit this recruitment at the endosome. PMID: 15657082
11. A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage PMID: 17671966

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HGNC: 11982

OMIM: 604700

KEGG: hsa:10043

STRING: 9606.ENSP00000413697

UniGene: Hs.474705