TP53AIP1 Antibody

1. results show that constitutional truncating TP53AIP1 mutations predispose to CMM in the French population PMID: 29359367
2. Data indicate that p53-regulated apoptosis-inducing protein 1 (p53AIP1) inhibits the proliferation of PC-3M cells, arrests cell cycle at S/G2-M phase, decreases the abilities of invasion and migration and promotes cell apoptosis. PMID: 25108434
3. These studies indicate the critical role of p53AIP1 under DNA damaging stresses for cell fate determination in rheumatoid arthritis-fibroblast-like synovioctes containing the p53R248Q mutation. PMID: 24316591
4. Apak competes with p53 for binding to inhibit p53AIP1 expression. PMID: 22334068
5. large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition PMID: 22457820
6. p53AIP1 regulates the mitochondrial apoptotic pathway. PMID: 12019168
7. The expression of Ki67 and p53 in various forms of leukoplakia point to the increasing instability of the genome in parallel with the severity of leukoplakia. PMID: 14707453
8. expression of the p53 mutant, R248Q, in liver cancer cells may enhance their drug resistance and upregulation of P-glycoprotein activity may contribute to this protective effect. PMID: 15004724
9. Roscovitine induced up-regulation of p53AIP1 protein and the depolarization of mitochondrial potential. PMID: 15657359
10. p53AIP1 gene is important for non-small cell lung cancer progression and may be a possible prognostic marker PMID: 17851056
11. Insufficient expression of p53AIP1 may play a role in gastric carcinogenesis in patients infected with H. pylori infection. PMID: 18277906
12. Data suggest that the combination of p53AIP1 and survivin gene expression may be a powerful tool to stratify subgroups with better or worse prognosis from the variable non-small cell lung cancer population. PMID: 19228369

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HGNC: 29984

OMIM: 605426

KEGG: hsa:63970

STRING: 9606.ENSP00000432743

UniGene: Hs.160953