TRDN Antibody, Biotin conjugated

Code CSB-PA024398LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRDN Polyclonal antibody
Uniprot No.
Target Names
TRDN
Alternative Names
dJ166D18.1 antibody; DKFZp779I2253 antibody; MGC88285 antibody; OTTHUMP00000040354 antibody; TDN antibody; TRDN antibody; TRDN_HUMAN antibody; Triadin antibody; TRISK 51 antibody; TRISK antibody; TRISK51 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Triadin protein (75-161AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Gene References into Functions
  1. The lncRNA TRDN-AS regulates the balance between cardiac and skeletal isoforms of triadin. PMID: 29126880
  2. CLIMP-63 (also known as CKAP4), is the partner of triadin, is responsible for this association of triads and microtubules. PMID: 27562070
  3. A compound heterozygous mutation in the triadin gene resulted in a particularly arrhythmogenic phenotype with with cardiac arrest in two siblings. PMID: 26768964
  4. We describe a new family with cathecholaminergic polymorphic ventricular tachycardia (CPVT) linked to the Triadin gene. PMID: 26200674
  5. Common variants in TRDN and CALM1 are associated with increased risk of sudden cardiac death in patients with chronic heart failure. PMID: 26196381
  6. TRDN is a novel underlying genetic basis for recessively inherited Long-QT syndrome. PMID: 25922419
  7. Data show that triadin (TRDN) is a new gene responsible for an autosomal recessive form of ctecholaminergic polymorphic ventricular tachycardia (CPVT). PMID: 22422768
  8. The researchers found evidence that TRDN may be a susceptibility or marker gene for IgA nephropathy PMID: 19890582
  9. gene organization and cloning of the major isoform PMID: 12659871
  10. Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart. PMID: 17526652
  11. proteasome inhibition led to an accumulation of two new modified forms of triadin-1 that were seen with triadin-1 only when it is not glycosylated on Asn(75). PMID: 18025088

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Involvement in disease
Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5)
Subcellular Location
Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
Database Links

HGNC: 12261

OMIM: 603283

KEGG: hsa:10345

STRING: 9606.ENSP00000381240

UniGene: Hs.144744

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