TRDN Antibody, HRP conjugated

Code CSB-PA024398LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRDN Polyclonal antibody
Uniprot No.
Target Names
TRDN
Alternative Names
dJ166D18.1 antibody; DKFZp779I2253 antibody; MGC88285 antibody; OTTHUMP00000040354 antibody; TDN antibody; TRDN antibody; TRDN_HUMAN antibody; Triadin antibody; TRISK 51 antibody; TRISK antibody; TRISK51 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Triadin protein (75-161AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Gene References into Functions
  1. The lncRNA TRDN-AS regulates the balance between cardiac and skeletal isoforms of triadin. PMID: 29126880
  2. CLIMP-63 (also known as CKAP4), is the partner of triadin, is responsible for this association of triads and microtubules. PMID: 27562070
  3. A compound heterozygous mutation in the triadin gene resulted in a particularly arrhythmogenic phenotype with with cardiac arrest in two siblings. PMID: 26768964
  4. We describe a new family with cathecholaminergic polymorphic ventricular tachycardia (CPVT) linked to the Triadin gene. PMID: 26200674
  5. Common variants in TRDN and CALM1 are associated with increased risk of sudden cardiac death in patients with chronic heart failure. PMID: 26196381
  6. TRDN is a novel underlying genetic basis for recessively inherited Long-QT syndrome. PMID: 25922419
  7. Data show that triadin (TRDN) is a new gene responsible for an autosomal recessive form of ctecholaminergic polymorphic ventricular tachycardia (CPVT). PMID: 22422768
  8. The researchers found evidence that TRDN may be a susceptibility or marker gene for IgA nephropathy PMID: 19890582
  9. gene organization and cloning of the major isoform PMID: 12659871
  10. Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart. PMID: 17526652
  11. proteasome inhibition led to an accumulation of two new modified forms of triadin-1 that were seen with triadin-1 only when it is not glycosylated on Asn(75). PMID: 18025088

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Involvement in disease
Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5)
Subcellular Location
Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
Database Links

HGNC: 12261

OMIM: 603283

KEGG: hsa:10345

STRING: 9606.ENSP00000381240

UniGene: Hs.144744

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