TREML1 Antibody, Biotin conjugated

Code CSB-PA771477LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TREML1 Polyclonal antibody
Uniprot No.
Target Names
TREML1
Alternative Names
dJ238O23.3 antibody; GLTL1825 antibody; MGC119173 antibody; PRO3438 antibody; TLT 1 antibody; TLT-1 antibody; TLT1 antibody; TREM like transcript 1 antibody; Trem like transcript 1 protein antibody; Trem-like transcript 1 protein antibody; TREML 1 antibody; Treml1 antibody; Triggering receptor expressed on myeloid cells like 1 antibody; Triggering receptor expressed on myeloid cells like protein 1 antibody; Triggering receptor expressed on myeloid cells-like protein 1 antibody; TRML1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Trem-like transcript 1 protein (16-162AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface receptor that may play a role in the innate and adaptive immune response.
Gene References into Functions
  1. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
  2. Levels of sTLT-1 in plasma from patients with potential acute coronary syndrome were compared with an age-matched control group with similar risk factors for cardiovascular disease. PMID: 25147325
  3. Platelet-derived soluble TLT-1 is a potent endogenous regulator of sepsis-associated inflammation. PMID: 22551551
  4. Serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for non-tuberculous mycobacterial lung disease. PMID: 22283904
  5. These results suggest that during inflammation, sTLT-1 may mediate hemostasis by enhancing actin polymerization, resulting in increased platelet aggregation and adherence to the endothelium. PMID: 20093931
  6. initial characterization of TREM-like transcript (TLT)-1 results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors(TLT-1) PMID: 12393607
  7. In contrast to previously characterized immunoreceptor tyrosine-based inhibition motif (ITIM) receptors, TLT1 enhances rather than inhibits calcium signaling in rat RBL-2H3 cells, a property dependent on the SHP-2 recruiting classical Tyr281 ITIM. PMID: 15128762
  8. A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin. PMID: 16505478
  9. Define a platelet specific function for TLT1 in regulation of aggregation. PMID: 17549298
  10. Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1. PMID: 18612537
  11. antibody against the extracellular domain inhibits platelet aggregation in vitro PMID: 19230638
  12. TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury PMID: 19436112

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
Tissue Specificity
Detected in platelets, monocytic leukemia and in T-cell leukemia.
Database Links

HGNC: 20434

OMIM: 609714

KEGG: hsa:340205

STRING: 9606.ENSP00000402855

UniGene: Hs.117331

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