TRIM3 Antibody

1. TRIM3 plays a tumor-suppressing role in the regulation of liver cancer development by reducing cell proliferation through cell cycle arrest at the G0/G1 phase. PMID: 28950898
2. The results of quantitative real-time RT-PCR and western blotting showed that the TRIM3 expression was very low in five cervical cancer cell lines. The TRIM3 overexpression weakened cell viability, and promote apoptosis of C-33A and SiHa cells in vitro, and inhibit tumor growth in vivo, which suggested that TRIM3 could reduce proliferation of cervical cancer cells. PMID: 29524410
3. TRIM3 exerted an anti-proliferation role in rheumatoid arthritis fibroblast-like synoviocytes via p38 signaling pathway. PMID: 28259936
4. results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD nuclear transport PMID: 26893479
5. TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein. PMID: 26691157
6. Studies indicate most-studied TRIpartite Motif (TRIM)-NHL proteins TRIM2, TRIM3, TRIM32 and TRIM71, and their mutations have been linked to diseases. PMID: 26514622
7. TRIM3 may play a significant role in hepatocellular carcinoma progression.TRIM3 is downregulated in hepatocellular carcinoma at both the mRNA and protein levels and that low TRIM3 expression is correlated with an unfavorable prognosis. PMID: 24994609
8. TRIM3 acts as a tumor suppressor in GBM by restoring asymmetric cell division. PMID: 24947043
9. Data indicate TRIM3 and p21 interact in cells. PMID: 23318451
10. TRIM63 is a candidate for genes mediating the glucocorticoid-induced promotion of osteoblastic differentiation. PMID: 20173306
11. brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53-dependent manner PMID: 20543135
12. the endosome-associated protein hrs is a subunit of a protein complex containing actinin-4, BERP, and myosin V that is necessary for efficient TfR recycling but not for EGFR degradation PMID: 15772161
13. Loss of heterozygosity of chromosome segment 11p15.5 in malignant gliomas suggests TRIM3 as a candidate brain tumor suppressor gene. PMID: 19250537

Show More

Hide All

HGNC: 10064

OMIM: 605493

KEGG: hsa:10612

STRING: 9606.ENSP00000340797

UniGene: Hs.591992