TRIM36 Antibody

Code CSB-PA868285LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA868285LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA868285LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRIM36 Polyclonal antibody
Uniprot No.
Target Names
TRIM36
Alternative Names
Acrosome RBCC protein antibody; E3 ubiquitin protein ligase TRIM36 antibody; E3 ubiquitin-protein ligase Trim36 antibody; Haprin antibody; RBCC728 antibody; RING finger protein 98 antibody; RNF98 antibody; TRI36_HUMAN antibody; TRIM 36 antibody; Trim36 antibody; Tripartite motif containing 36 antibody; Tripartite motif containing protein 36 antibody; Tripartite motif protein 36 antibody; Tripartite motif-containing protein 36 antibody; Zinc binding protein Rbcc728 antibody; Zinc-binding protein Rbcc728 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase TRIM36 protein (70-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TRIM36 Antibody (Product code: CSB-PA868285LA01HU) is Non-conjugated. For TRIM36 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA868285LB01HU TRIM36 Antibody, HRP conjugated ELISA
FITC CSB-PA868285LC01HU TRIM36 Antibody, FITC conjugated
Biotin CSB-PA868285LD01HU TRIM36 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
Gene References into Functions
  1. aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure PMID: 28359976
  2. The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly . PMID: 28087737
  3. TRIM36 is the causative gene for autosomal recessive anencephaly PMID: 28087737
  4. The overexpression of the TRIM36 in the vast majority of prostate cancer suggest that this gene might be involved in the prostate tumorigenesis. PMID: 15145053
  5. molecular cloning and characterization of a human haprin ortholog. PMID: 15955891
  6. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H, potentially associated with chromosome segregation and its excess may cause chromosomal instability. PMID: 19232519

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Involvement in disease
Anencephaly (ANPH)
Subcellular Location
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton.
Protein Families
TRIM/RBCC family
Tissue Specificity
Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. Expressed in fetal tissues.
Database Links

HGNC: 16280

OMIM: 206500

KEGG: hsa:55521

STRING: 9606.ENSP00000282369

UniGene: Hs.519514

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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