TRPC4AP Antibody

Datasheet

Code	CSB-PA777153
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA777153(TRPC4AP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

Q8TEL6

Target Names

TRPC4AP

Alternative Names

antibody; TRPC4AP antibody; Chromosome 20 open reading frame 188 antibody; Protein TAP1 antibody; Protein TRUSS antibody; Short transient receptor potential channel 4 associated protein antibody; Short transient receptor potential channel 4-associated protein antibody; TAP1 protein antibody; TNF receptor ubiquitous scaffolding/signaling protein antibody; TNF-receptor ubiquitous scaffolding/signaling protein antibody; TP4AP_HUMAN antibody; Transient receptor potential cation channel; subfamily C; member 4 associated protein antibody; Trp4 associated protein antibody; Trp4-associated protein antibody; Trpc4 associated protein antibody; Trpc4-associated protein antibody; TRPC4AP antibody; TRRP4AP antibody; TRUSS antibody; Tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human TRPC4AP

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:10000
IHC	1:30-1:150

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Gene References into Functions

TRUSS is a novel substrate of E3 ligase Skp2. PMID: 26038816
The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years. PMID: 19059308
These findings suggest that TNF-R1, TRUSS, and TRPC4 augment Ca(2+) loading of endoplasmic reticulum Ca(2+) stores in the context of m1AchR stimulation PMID: 20458742
TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus PMID: 20551172
results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families PMID: 18449908

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Subcellular Location

Cytoplasm, perinuclear region.

Database Links

HGNC: 16181

OMIM: 608430

KEGG: hsa:26133

STRING: 9606.ENSP00000252015

UniGene: Hs.168073

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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