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TSC22D1 Antibody

Datasheet
Code CSB-PA623011LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TSC22D1 Polyclonal antibody
Uniprot No.
Q15714
Target Names
TSC22D1
Alternative Names
Cerebral protein 2 antibody; DKFZp686O19206 antibody; Hucep 2 antibody; Hucep2 antibody; KIAA1994 antibody; MGC17597 antibody; OTTHUMP00000040978 antibody; Ptg 2 antibody; Regulatory protein TSC 22 antibody; Regulatory protein TSC-22 antibody; Regulatory protein TSC22 antibody; RP11 269C23.2 antibody; T22D1_HUMAN antibody; TGFB stimulated clone 22 homolog antibody; TGFB-stimulated clone 22 homolog antibody; TGFB1I4 antibody; TGFbeta stimulated clone 22 antibody; Transcriptional regulator TSC 22 antibody; Transforming growth factor beta 1 induced transcript 4 antibody; Transforming growth factor beta 1 induced transcript 4 protein antibody; Transforming growth factor beta stimulated protein TSC 22 antibody; Transforming growth factor beta-1-induced transcript 4 protein antibody; TSC 22 antibody; TSC22 antibody; TSC22 domain family 1 isoform 2 antibody; TSC22 domain family member 1 antibody; TSC22 domain family protein 1 antibody; TSC22D1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TSC22 domain family protein 1 protein (1-144AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TSC22D1 Antibody (Product code: CSB-PA623011LA01HU) is Non-conjugated. For TSC22D1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA623011LB01HU TSC22D1 Antibody, HRP conjugated ELISA
FITC CSB-PA623011LC01HU TSC22D1 Antibody, FITC conjugated
Biotin CSB-PA623011LD01HU TSC22D1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

TSC22D1 Antibodies

TSC22D1 Proteins

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Target Background

Function
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
Gene References into Functions
  1. TSC22 could suppress tumor by inhibiting cell proliferation in colorectal cancer cell lines. Multivariate Cox regression analysis confirmed TSC22 expression as independent predictors of the OS in CRC patients PMID: 29481799
  2. TSC-22 acts as a tumor suppressor by safeguarding p53 from poly-ubiquitination mediated-degradation. PMID: 22870275
  3. we report that induced Tsc-22 leads to enhancement of TGF-beta-dependent signaling and enhancement is blocked by expression of a dominant-negative Tsc-22 mutant PMID: 21881999
  4. Differential regulation of antagonistic TSC22D1 variants is required for the establishment of oncogene-induced cellular senescence. PMID: 21448135
  5. Results support role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-beta-induced upregulation of CNP expression in smooth muscle may be mediated in part by increased transcription of TSC22D1. PMID: 20802130
  6. Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential. PMID: 20149264
  7. Leucine Zipper structure of TSC22 markedly inhibits the anchorage independent growth of salivary gland cancer cells PMID: 11836610
  8. TSC-22 is an important downstream component of PPARgamma and TGF-beta signaling during intestinal epithelial cell differentiation PMID: 12468551
  9. findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy PMID: 12757981
  10. Upregulation of TSC-22 mRNA by TGF-beta 1 is achieved by mRNA stabilization. PMID: 12767908
  11. Tsc-22 modulates the TGF-beta-dependant signaling pathway and binds to and modulate the transcriptional activity of Smad3 and Smad4. It has effect on cellular differentiation PMID: 15881652
  12. expression of TSC-22 in prostate is restricted to basal layer; maybe useful marker for differentation between normal and malignant acinar epithelium of prostate PMID: 16106424
  13. TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD PMID: 17690703
  14. Expression of TSC-22 was frequently observed in the tumor cells with differentiated-phenotypes, although rarely in the cells with growing potentials. PMID: 18288391
  15. interaction between fortilin and TSC-22 prevents apoptosis via the destabilization of TSC-22 in ovarian carcinoma cells PMID: 18325344

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
TSC-22/Dip/Bun family
Tissue Specificity
Widely expressed in fetal and adult tissues.
Database Links

HGNC: 16826

OMIM: 607715

KEGG: hsa:8848

STRING: 9606.ENSP00000397435

UniGene: Hs.436383

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