TSC22D1 Antibody

1. TSC22 could suppress tumor by inhibiting cell proliferation in colorectal cancer cell lines. Multivariate Cox regression analysis confirmed TSC22 expression as independent predictors of the OS in CRC patients PMID: 29481799
2. TSC-22 acts as a tumor suppressor by safeguarding p53 from poly-ubiquitination mediated-degradation. PMID: 22870275
3. we report that induced Tsc-22 leads to enhancement of TGF-beta-dependent signaling and enhancement is blocked by expression of a dominant-negative Tsc-22 mutant PMID: 21881999
4. Differential regulation of antagonistic TSC22D1 variants is required for the establishment of oncogene-induced cellular senescence. PMID: 21448135
5. Results support role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-beta-induced upregulation of CNP expression in smooth muscle may be mediated in part by increased transcription of TSC22D1. PMID: 20802130
6. Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential. PMID: 20149264
7. Leucine Zipper structure of TSC22 markedly inhibits the anchorage independent growth of salivary gland cancer cells PMID: 11836610
8. TSC-22 is an important downstream component of PPARgamma and TGF-beta signaling during intestinal epithelial cell differentiation PMID: 12468551
9. findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy PMID: 12757981
10. Upregulation of TSC-22 mRNA by TGF-beta 1 is achieved by mRNA stabilization. PMID: 12767908
11. Tsc-22 modulates the TGF-beta-dependant signaling pathway and binds to and modulate the transcriptional activity of Smad3 and Smad4. It has effect on cellular differentiation PMID: 15881652
12. expression of TSC-22 in prostate is restricted to basal layer; maybe useful marker for differentation between normal and malignant acinar epithelium of prostate PMID: 16106424
13. TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD PMID: 17690703
14. Expression of TSC-22 was frequently observed in the tumor cells with differentiated-phenotypes, although rarely in the cells with growing potentials. PMID: 18288391
15. interaction between fortilin and TSC-22 prevents apoptosis via the destabilization of TSC-22 in ovarian carcinoma cells PMID: 18325344

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HGNC: 16826

OMIM: 607715

KEGG: hsa:8848

STRING: 9606.ENSP00000397435

UniGene: Hs.436383