TSEN15 Antibody

Datasheet

Code	CSB-PA840989LA01HU
Size	US$166
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Image	IHC image of CSB-PA840989LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA840989LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TSEN15 Polyclonal antibody

Uniprot No.

Q8WW01

Target Names

TSEN15

Alternative Names

TSEN15 antibody; C1orf19 antibody; SEN15 antibody; tRNA-splicing endonuclease subunit Sen15 antibody; SEN15 homolog antibody; HsSEN15 antibody; tRNA-intron endonuclease Sen15 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TSEN15 Antibody (Product code: CSB-PA840989LA01HU) is Non-conjugated. For TSEN15 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA840989LB01HU	TSEN15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA840989LC01HU	TSEN15 Antibody, FITC conjugated
Biotin	CSB-PA840989LD01HU	TSEN15 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.

Gene References into Functions

results demonstrate that mutations in any known subunit of the TSEN complex can cause pontocerebellar hypoplasia and progressive microcephaly, emphasizing the importance of its function during brain development PMID: 27392077
A candidate SNP associated with the tRNA-splicing protein gene TSEN15 was independently associated with the risk of atrial fibrillation. PMID: 24944287

Involvement in disease

Pontocerebellar hypoplasia 2F (PCH2F)

Subcellular Location

Nucleus. Nucleus, nucleolus.

Protein Families

SEN15 family

Tissue Specificity

Widely expressed. Highly expressed in testis and uterus.

Database Links

HGNC: 16791

OMIM: 608756

KEGG: hsa:116461

STRING: 9606.ENSP00000355299

UniGene: Hs.548197

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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