TSHZ1 Antibody

Code CSB-PA006423
Size US$100
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Product Details

Uniprot No.
Target Names
TSHZ1
Alternative Names
TSHZ1 antibody; SDCCAG33 antibody; TSH1 antibody; Teashirt homolog 1 antibody; Antigen NY-CO-33 antibody; Serologically defined colon cancer antigen 33 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of Human TSHZ1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
Gene References into Functions
  1. TSHZ1 levels are reduced in human islets of donors with type 2 diabetes PMID: 25918232
  2. TSHZ1 is a key regulator of mammalian olfactory bulb development and function and controls the expression of PROKR2. PMID: 24487590
  3. Together, these results demonstrate that hemizygosity of TSHZ1 leads to congenital aural atresia as a result of haploinsufficiency PMID: 22152683
  4. a significant up-regulation of BORIS (p<0.001) and TSHZ1 transcripts (p<0.05) for JAs compared to nasal mucosa. PMID: 21874228
  5. This publication characterizes the mouse ortholog of the human teashirt zinc finger homeobox 1 gene and proposes that the human gene may be a candidate gene for CAA syndrome. PMID: 17586487

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Involvement in disease
Aural atresia, congenital (CAA)
Subcellular Location
Nucleus.
Protein Families
Teashirt C2H2-type zinc-finger protein family
Tissue Specificity
Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
Database Links

HGNC: 10669

OMIM: 607842

KEGG: hsa:10194

STRING: 9606.ENSP00000323584

UniGene: Hs.284217

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