TTF2 Antibody

Datasheet

Code	CSB-PA120090
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA120090(TTF2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

Q9UNY4

Target Names

TTF2

Alternative Names

F2 antibody; Factor 2 antibody; Factor2 antibody; HuF 2 antibody; HuF2 antibody; Human factor 2 antibody; Lodestar homolog antibody; Lodestar protein antibody; RNA polymerase II termination factor antibody; Transcription release factor 2 antibody; Transcription termination factor 2 antibody; Transcription termination factor RNA polymerase II antibody; TTF2 antibody; TTF2_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human TTF2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:5-1:20

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Gene References into Functions

hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing PMID: 12927788
TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase. PMID: 15125840
Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes. PMID: 15467445

Subcellular Location

Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.

Protein Families

SNF2/RAD54 helicase family

Database Links

HGNC: 12398

OMIM: 604718

KEGG: hsa:8458

STRING: 9606.ENSP00000358478

UniGene: Hs.32333

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Th17 cell differentiation Thyroid hormone synthesis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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