TXNL4A Antibody, HRP conjugated

Code CSB-PA025386LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TXNL4A Polyclonal antibody
Uniprot No.
Target Names
TXNL4A
Alternative Names
TXNL4A antibody; DIM1 antibody; TXNL4Thioredoxin-like protein 4A antibody; DIM1 protein homolog antibody; Spliceosomal U5 snRNP-specific 15 kDa protein antibody; Thioredoxin-like U5 snRNP protein U5-15kD antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Thioredoxin-like protein 4A protein (1-142AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Gene References into Functions
  1. Recessive variants in TXNL4A were identified in two individuals with Burn-McKeown syndrome as well as in three individuals (from two families) with isolated choanal atresia. PMID: 28905882
  2. Reporter gene and in vivo assays showed that the promoter deletions led to reduced expression of TXNL4A. Depletion of TXNL4A (Dib1) in yeast demonstrated reduced assembly of the tri-snRNP complex. PMID: 25434003
  3. human dim1 is a peptidase with autocleavage activity that results in a thioredoxin-like core PMID: 17177886
Involvement in disease
Burn-McKeown syndrome (BMKS)
Subcellular Location
Nucleus.
Protein Families
DIM1 family
Database Links

HGNC: 30551

OMIM: 608572

KEGG: hsa:10907

STRING: 9606.ENSP00000269601

UniGene: Hs.465498

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