U2AF1L4 Antibody

Code CSB-PA837850ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA837850ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) U2AF1L4 Polyclonal antibody
Uniprot No.
Target Names
U2AF1L4
Alternative Names
FLJ35525 antibody; MGC33901 antibody; Splicing factor U2AF 26 kDa subunit antibody; U2 auxiliary factor 26 antibody; U2 small nuclear RNA auxiliary factor 1 like 3 antibody; U2 small nuclear RNA auxiliary factor 1 like 4 antibody; U2 small nuclear RNA auxiliary factor 1 like protein 3 antibody; U2 small nuclear RNA auxiliary factor 1 like protein 4 antibody; U2 small nuclear RNA auxiliary factor 1-like protein 3 antibody; U2 small nuclear RNA auxiliary factor 1-like protein 4 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1 like 3 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 antibody; U2AF1 like protein 3 antibody; U2AF1 RS3 antibody; U2AF1-like protein 3 antibody; U2AF1L3V1 antibody; U2AF1L4 antibody; U2AF1RS3 antibody; U2af26 antibody; U2AF4_HUMAN antibody; U2RNU2 small nuclear RNA auxiliary factor 1 like 3 antibody; U2RNU2 small nuclear RNA auxiliary factor 1 like protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Splicing factor U2AF 26 kDa subunit protein (1-202AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA.
Gene References into Functions
  1. U2AF1L4 gene expression is regulated by cytokines in activated T cells. PMID: 27143377
  2. One of the conservative regions is responsible for the enhancer activity and is able to interact with proteins of HeLa cell nuclear extract. PMID: 22022969
  3. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26 PMID: 18460468
Subcellular Location
Nucleus. Nucleus speckle. Cytoplasm.
Protein Families
Splicing factor SR family
Tissue Specificity
Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.
Database Links

HGNC: 23020

OMIM: 601080

KEGG: hsa:199746

UniGene: Hs.351558

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