UBA52 Antibody, Biotin conjugated

Datasheet
Code CSB-PA025416LD01HU
Size US$299
Uniprot No. P62987
Protocols ELISA Protocol
Immunogen Recombinant Human Ubiquitin-60S ribosomal protein L40 protein (1-128AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Ubiquitin-60S ribosomal protein L40 (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (Large ribosomal subunit protein eL40)], UBA52, UBCEP2
Immunogen Species Homo sapiens (Human)
Research Area Epigenetics and Nuclear Signaling
Target Names UBA52
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Ubiquitin
Subcellular Location Ubiquitin: Cytoplasm, Nucleus, SUBCELLULAR LOCATION: 60S ribosomal protein L40: Cytoplasm
Protein Families Ubiquitin family; Eukaryotic ribosomal protein eL40 family
Database Links

HGNC: 12458

OMIM: 191321

KEGG: hsa:7311

STRING: 9606.ENSP00000388107

UniGene: Hs.5308

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