UBE2N Antibody, HRP conjugated

Code CSB-PA025470LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UBE2N Polyclonal antibody
Uniprot No.
Target Names
UBE2N
Alternative Names
Bendless like ubiquitin conjugating enzyme antibody; Bendless-like ubiquitin-conjugating enzyme antibody; BLU antibody; EC 6.3.2.19 antibody; Epididymis secretory protein Li 71 antibody; HEL-S-71 antibody; Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds antibody; MGC131857 antibody; MGC8489 antibody; UBC 13 antibody; Ubc13 antibody; UbCH ben antibody; UbcH-ben antibody; UbcH13 antibody; UBCHBEN antibody; Ube 2N antibody; Ube2n antibody; UBE2N_HUMAN antibody; Ubiquitin carrier protein N antibody; Ubiquitin conjugating enzyme E2 N antibody; Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) antibody; Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast) antibody; Ubiquitin conjugating enzyme E2N antibody; Ubiquitin protein ligase N antibody; Ubiquitin-conjugating enzyme E2 N antibody; Ubiquitin-protein ligase N antibody; Yeast UBC13 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin-conjugating enzyme E2 N protein (20-138AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
Gene References into Functions
  1. Uev1A-Ubc13 complex catalyzes lysine63-linked ubiquitination of RHBDF2 to promote TACE maturation. PMID: 29069608
  2. The malin-laforin complex interacts physically and functionally with the ubiquitin conjugating enzyme E2-N (UBE2N). PMID: 26546463
  3. together with UBE2L3 and UBE2D2, synergistically contribute to Parkin-mediated mitophagy PMID: 24906799
  4. MiR-205 inhibits DNA damage repair by targeting ZEB1 and Ubc13. PMID: 25476932
  5. Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-small ka, CyrillicB mediated matrix metalloproteinase-1 gene regulation. PMID: 25022892
  6. Ubc13 was dispensable for transforming growth factor beta (TGFbeta)-induced SMAD activation but was required for activation of non-SMAD signaling via TGFbeta-activating kinase 1 (TAK1) and p38 PMID: 25189770
  7. UBE2N inhibition induces neuroblastoma apoptotic cell death via activation of p53 and JNK pathways. PMID: 24556694
  8. overexpression of hsa-miR-4516 downregulates STAT3, p-STAT3, CDK6, and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells. PMID: 24610393
  9. crystal structure of the Shigella flexneri OspI-Ubc13 complex at 2.3 A resolution; study reveals the molecular basis of Ubc13 deamidation by OspI, as well as a convergence of E2 recognition by bacterial and host proteins PMID: 23633953
  10. The structure of the Shigella flexneri OspI and human Ubc13 complex revealed that the interacting surfaces between OspI and Ubc13 are a hydrophobic surface and a complementary charged surface. PMID: 23542009
  11. Data show RING finger (RNF) E3 ubiquitin ligase RNF8 dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13/Mms2 with formation of Lys-63 ubiquitin chains, whereas the RNF168 RING domain is a monomer and does not catalyze Lys-6 ubiquitylation. PMID: 22589545
  12. the crystal structure of human OTUB1 in complex with human UBC13 and MMS2 PMID: 22679021
  13. Data show that growth hormone receptor (GHR) endocytosis requires both ubiquitin-conjugating enzyme Ubc13 and the ubiquitin ligase COOH terminus of Hsp70 interacting protein (CHIP). PMID: 22433856
  14. the interation between RAP80 and MDC1 is dependent upon the UBC13 mediated ubiquitination of MDC1 at K-1977 PMID: 21622030
  15. entire coding region and splice junctions of RNF8, UBC13 and MMS2 genes were screened for mutations in affected index cases from 123 Northern Finnish breast cancer families PMID: 21774837
  16. An NMR-based model of the ubiquitin-bound human complex and the structural basis of lysine 63 chain catalysis. PMID: 12569095
  17. Ubc13-Mms2 and Lys63-polyubiquitin chains are associated with signaling cellular stress PMID: 14562038
  18. The results in this study allowed identification of important residues of the Ubc13-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 but not other Ubc proteins. PMID: 15749714
  19. ISGylation of Ubc13 disrupts its ability to form thioester bond with ubiquitin PMID: 16122702
  20. These data reveal a critical and unexpected role for vertebrate Ubc13 in the initiation of homologous recombination at the level of double-strand break processing. PMID: 17349954
  21. modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism PMID: 17709375
  22. Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-kappaB activation. PMID: 17942533
  23. the human Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage PMID: 18077395
  24. RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP. PMID: 19269966
  25. crystal structures of TRAF6 and its complex with the ubiquitin-conjugating enzyme (E2) Ubc13 PMID: 19465916
  26. regulation of p53 multimerization that requires the concerted action of JNK and Ubc13 on polysome-bound p53. PMID: 19651615
  27. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527
  28. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380
  29. This paper describes the function of the mouse protein, but suggests the function of the human protein, since both human and mouse proteins are 100% identical. PMID: 12039045

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Ubiquitin-conjugating enzyme family
Database Links

HGNC: 12492

OMIM: 603679

KEGG: hsa:7334

STRING: 9606.ENSP00000316176

UniGene: Hs.524630

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