UNC50 Antibody, FITC conjugated

Code CSB-PA687496LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UNC50 Polyclonal antibody
Uniprot No.
Target Names
UNC50
Alternative Names
UNC50; UNCL; HSD-23; HSD23; Protein unc-50 homolog; Periodontal ligament-specific protein 22; PDLs22; Protein GMH1 homolog; hGMH1; Uncoordinated-like protein
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein unc-50 homolog protein (15-82AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the cell surface expression of neuronal nicotinic receptors. Binds RNA.
Gene References into Functions
  1. Data indicate that biallelic mutation in the UNC50 gene underlies AMC through a probable loss of AChR expression at the neuromuscular junction which is essential for the cholinergic transmission during human muscle development. PMID: 29016857
  2. depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosomal degradation of STx2. UNC50 acted by recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi. PMID: 28883040
  3. UNC50 may plays some roles in HCC progression by affecting the EGFR pathway PMID: 25738771
  4. UNCL plays important roles in the development, differentiation, and maintenance of periodontal tissues and in the mechanotransduction of periodontal ligament fibroblasts. PMID: 17004066
Subcellular Location
Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families
Unc-50 family
Tissue Specificity
Present in periodontal ligament fibroblasts (at protein level).
Database Links

HGNC: 16046

OMIM: 617826

KEGG: hsa:25972

STRING: 9606.ENSP00000350409

UniGene: Hs.13370

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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