UVSSA Antibody, Biotin conjugated

Datasheet
Code CSB-PA012267LD01HU
Size US$299
Uniprot No. Q2YD98
Immunogen Recombinant Human UV-stimulated scaffold protein A protein (143-206AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias UV-stimulated scaffold protein A, UVSSA, KIAA1530
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Others
Target Names UVSSA
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
Involvement in disease UV-sensitive syndrome 3 (UVSS3)
Subcellular Location Chromosome
Protein Families UVSSA family
Database Links

HGNC: 29304

OMIM: 614632

KEGG: hsa:57654

STRING: 9606.ENSP00000374501

UniGene: Hs.380475

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