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VOPP1 Antibody, FITC conjugated

Datasheet
Code CSB-PA03544C0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) VOPP1 Polyclonal antibody
Uniprot No.
Q96AW1
Target Names
VOPP1
Alternative Names
VOPP1 antibody; ECOP antibody; GASP antibody; Vesicular antibody; overexpressed in cancer antibody; prosurvival protein 1 antibody; EGFR-coamplified and overexpressed protein antibody; ECop antibody; Glioblastoma-amplified secreted protein antibody; Putative NF-kappa-B-activating protein 055N antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Vesicular, overexpressed in cancer, prosurvival protein 1 protein (23-172AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
Gene References into Functions
  1. miR-218 inhibits human lung adenocarcinoma cell migration and invasion via the suppression of Ecop and Robo1 expression PMID: 28936884
  2. Candidate gene eQTL showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene, previously linked to altered BB response, and high expression of VOPP1. PMID: 26860460
  3. VOPP1 is overexpressed in gastric adenocarcinoma, which is involved in promoting cell proliferation and migration and thus might serve as a putative oncogene. PMID: 25398664
  4. Upregulation of ECOP is associated with glioma. PMID: 23243056
  5. overexpression in cancer participates in the control of the intracellular redox state; its loss leads to oxidative cellular injury leading to cell death by the intrinsic apoptotic pathway PMID: 21519330
  6. ECOP was used as a molecular marker in patients with chronic wounds to guide surgical debridement. PMID: 17515955
  7. Results identify ECOP as a protein relevant to the biology of SCC. PMID: 19525979

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Subcellular Location
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.
Protein Families
VOPP1/ECOP family
Tissue Specificity
Widely expressed with highest levels in thymus and ovary.
Database Links

HGNC: 34518

OMIM: 611915

KEGG: hsa:81552

STRING: 9606.ENSP00000285279

UniGene: Hs.488307

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