VPS36 Antibody, HRP conjugated

Datasheet

Code	CSB-PA801240OB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) VPS36 Polyclonal antibody

Uniprot No.

Q86VN1

Target Names

VPS36

Alternative Names

C13orf9 antibody; CGI 145 antibody; EAP45 antibody; ELL associated protein of 45 kDa antibody; ELL-associated protein of 45 kDa antibody; ESCRT-II complex subunit VPS36 antibody; Vacuolar protein sorting associated protein 36 antibody; Vacuolar protein-sorting-associated protein 36 antibody; Vps36 antibody; VPS36_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Peptide sequence from Human Vacuolar protein-sorting-associated protein 36 protein (87-105AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Gene References into Functions

RAB27A, RAB27B and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B and VPS36, with RAB27A and RAB27B being dependent on VPS36. PMID: 28197629
Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. PMID: 17057716

Subcellular Location

Cytoplasm. Endosome. Late endosome. Membrane. Nucleus.

Protein Families

VPS36 family

Database Links

HGNC: 20312

OMIM: 610903

KEGG: hsa:51028

STRING: 9606.ENSP00000367299

UniGene: Hs.109520

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Protein Service

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Related pathways

Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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