VPS54 Antibody

1. This study suggests that VPS54 mutations are not a common cause of Amyotrophic Lateral Sclerosis in Italian population PMID: 21087364
2. Golgi-associated retrograde protein orchestrates retrograde transport from endosomes to the trans-Golgi network by promoting vesicle tethering and assembly of SNARE complexes in consecutive, independent steps.[Golgi associated retrograde protein] PMID: 19620288
3. Severely reduced levels of mutant Vps54 and, consequently, of the whole GARP complex underlie the phenotype of the wobbler mouse. PMID: 20615984
4. Golgi associated retrograde protein complex, consisting of the Vps52, Vps53, and Vps54 proteins, shows significant conservation between various species but diversification and specialization result in important differences in human cells. PMID: 15878329
5. Missorting of cathepsin D in GARP-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes. PMID: 18367545
6. mutations in VPS54 are not a major cause of ALS (amyotrophic lateral sclerosis) PMID: 18574757
7. PMID:12039048 mostly pertains to mouse and rat but contains some general comments about the structure and function of Vps54 homolog in other species, including human. PMID: 12039048

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HGNC: 18652

OMIM: 614633

KEGG: hsa:51542

STRING: 9606.ENSP00000272322

UniGene: Hs.48499