VTI1A Antibody

Datasheet

Code	CSB-PA842635LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA842635LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA842635LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA842635LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) VTI1A Polyclonal antibody

Uniprot No.

Q96AJ9

Target Names

VTI1A

Alternative Names

MMDS3 antibody; MVti1 antibody; SNARE Vti1a beta protein antibody; Vesicle transport through interaction with t-SNAREs homolog 1A antibody; Vesicle transport through interaction with tSNAREs homolog 1A (yeast) antibody; Vesicle transport v-SNARE protein Vti1-like 2 antibody; Vti1 rp2 antibody; Vti1-rp2 antibody; Vti1a antibody; VTI1A vesicle transport through interaction with t-SNAREs 1A antibody; VTI1A_HUMAN antibody; VTI1RP2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Vesicle transport through interaction with t-SNAREs homolog 1A protein (1-175AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The VTI1A Antibody (Product code: CSB-PA842635LA01HU) is Non-conjugated. For VTI1A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA842635LB01HU	VTI1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA842635LC01HU	VTI1A Antibody, FITC conjugated
Biotin	CSB-PA842635LD01HU	VTI1A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

Gene References into Functions

Novel variants of VTI1A-TCF7L2 fusion transcripts, including a novel fusion partner gene, RP11-57H14.3, was identified and demonstrated detectable levels in a large fraction of colorectal cancer samples.[RP11-57H14.3] PMID: 24608966
our results indicate that genetic variants in VTI1A may modify individual susceptibility to non-GBM of glioma in the Han Chinese population and support the role of the VTI1A genes in the occurrence of glioma. PMID: 28320150
The AA genotype of VTI1A (rs7086803) polymorphism had an increased risk of developing NSCLC compared with the GG genotype. Smoking lung cancer patients with the AA genotype of VTI1A gene (rs7086803) had a poor survival rate. PMID: 25744365
analysis of a new susceptibility locus for colorectal cancer in VTI1A [meta-analysis] PMID: 25105248
Data indicate that depletion of VAMP4, syntaxin 6, syntaxin 16, and Vti1a disrupted the Golgi ribbon structure. PMID: 23677696
We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. PMID: 21892161
The present results suggest that a SNARE complex containing VAMP7 and Vti1a defines a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells. PMID: 19138172

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Subcellular Location

Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein.

Protein Families

VTI1 family

Database Links

HGNC: 17792

OMIM: 614316

KEGG: hsa:143187

STRING: 9606.ENSP00000376792

UniGene: Hs.194554

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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