WDR19 Antibody

Datasheet

Code	CSB-PA836733LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836733LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA836733LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA836733LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) WDR19 Polyclonal antibody

Uniprot No.

Q8NEZ3

Target Names

WDR19

Alternative Names

DYF 2 antibody; DYF2 antibody; FLJ23127 antibody; IFT144 antibody; Intraflagellar transport 144 homolog antibody; KIAA1638 antibody; ORF26 antibody; Oseg6 antibody; PWDMP antibody; WD repeat containing protein 19 antibody; WD repeat domain 19 antibody; WD repeat membrane protein PWDMP antibody; WD repeat-containing protein 19 antibody; Wdr19 antibody; WDR19_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human WD repeat-containing protein 19 protein (45-226AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The WDR19 Antibody (Product code: CSB-PA836733LA01HU) is Non-conjugated. For WDR19 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836733LB01HU	WDR19 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836733LC01HU	WDR19 Antibody, FITC conjugated
Biotin	CSB-PA836733LD01HU	WDR19 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport.

Gene References into Functions

Case Reports: that WDR19 mutations can cause dysplastic kidney in addition to nephronophthisis in infants with Sensenbrenner syndrome. PMID: 28621010
Nephronophthisis 13 (Autosomal Recessive Polycystic Kidney Disease) is associated with mutations in the WDR19 gene.Caroli disease is a major extra-renal phenotype associated with mutations in WDR19 in the Korean population. PMID: 25726036
WDR19 mutations can cause a broad spectrum of ciliopathies that extends to Jeune and Sensenbrenner syndromes, RP and renal NPHP-like phenotypes PMID: 24504730
Mutations in WDR19 gene is associated with Caroli disease. PMID: 23559409
WDR19: an ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior-Loken syndrome. PMID: 23683095
Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19 PMID: 22019273
Expressed in normal and neoplastic prostate epithelium and is regulated by androgenic hormones. PMID: 12906858
Overexpression of WDR19 is associated with prostate cancer PMID: 18316561

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Involvement in disease

Cranioectodermal dysplasia 4 (CED4); Short-rib thoracic dysplasia 5 with or without polydactyly (SRTD5); Nephronophthisis 13 (NPHP13); Senior-Loken syndrome 8 (SLSN8)

Subcellular Location

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment.

Tissue Specificity

Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal epithelial cells. No expression detected in fibromu

Database Links

HGNC: 18340

OMIM: 608151

KEGG: hsa:57728

STRING: 9606.ENSP00000382717

UniGene: Hs.438482

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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