WDR24 Antibody

Datasheet

Code	CSB-PA836297LA01HU
Size	US$166
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Image	IHC image of CSB-PA836297LA01HU diluted at 1:200 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) WDR24 Polyclonal antibody

Uniprot No.

Q96S15

Target Names

WDR24

Alternative Names

C16orf21 antibody; DKFZp434F054 antibody; JFP7 antibody; LA16c-313D11.2 antibody; WD repeat-containing protein 24 antibody; wdr24 antibody; WDR24_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human GATOR complex protein WDR24 protein (1-298AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The WDR24 Antibody (Product code: CSB-PA836297LA01HU) is Non-conjugated. For WDR24 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836297LB01HU	WDR24 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836297LC01HU	WDR24 Antibody, FITC conjugated
Biotin	CSB-PA836297LD01HU	WDR24 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.

Gene References into Functions

Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells PMID: 27166823

Subcellular Location

Lysosome membrane.

Protein Families

WD repeat WDR24 family

Database Links

HGNC: 20852

KEGG: hsa:84219

STRING: 9606.ENSP00000293883

UniGene: Hs.459632

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

mTOR signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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