WDR24 Antibody

Datasheet
Code CSB-PA836297LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q96S15
Image
  • IHC image of CSB-PA836297LA01HU diluted at 1:200 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human GATOR complex protein WDR24 protein (1-298AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Relevance As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias GATOR complex protein WDR24 (WD repeat-containing protein 24), WDR24, C16orf21
Immunogen Species Homo sapiens (Human)
Research Area Cell Biology
Target Names WDR24
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway
Subcellular Location Lysosome membrane
Protein Families WD repeat WDR24 family
Database Links

HGNC: 20852

KEGG: hsa:84219

STRING: 9606.ENSP00000293883

UniGene: Hs.459632

Pathway mTOR signaling pathway

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