WDR41 Antibody

Code CSB-PA864011LA01HU
Size US$166
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Image
  • Immunofluorescence staining of U251 cells with CSB-PA864011LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) WDR41 Polyclonal antibody
Uniprot No.
Target Names
WDR41
Alternative Names
FLJ10904 antibody; MSTP048 antibody; WD repeat domain 41 antibody; WD repeat protein 41 antibody; WD repeat-containing protein 41 antibody; WDR 41 antibody; WDR41 antibody; WDR41_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human WD repeat-containing protein 41 protein (7-284AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The WDR41 Antibody (Product code: CSB-PA864011LA01HU) is Non-conjugated. For WDR41 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA864011LB01HU WDR41 Antibody, HRP conjugated ELISA
FITC CSB-PA864011LC01HU WDR41 Antibody, FITC conjugated
Biotin CSB-PA864011LD01HU WDR41 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Gene References into Functions
  1. Study describes the identification of two binding partners for C9orf72: SMCR8 and WDR41 and demonstrated that C9orf72/SMCR8/WDR41 interacts with the FIP200/Ulk1/ATG13/ATG101 complex. PMID: 27193190
  2. The peak of association was found in and around two genes, WDR41 and PDE8B, involved in dopamine signaling and development. PMID: 21502949
Subcellular Location
Cytoplasm.
Database Links

HGNC: 25601

OMIM: 617502

KEGG: hsa:55255

STRING: 9606.ENSP00000296679

UniGene: Hs.482573

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