WRB Antibody, Biotin conjugated

Code CSB-PA026148LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) WRB Polyclonal antibody
Uniprot No.
Target Names
WRB
Alternative Names
GET1; CHD5; WRB; Guided entry of tail-anchored proteins factor 1; Congenital heart disease 5 protein; Tail-anchored protein insertion receptor WRB; Tryptophan-rich basic protein
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tail-anchored protein insertion receptor WRB protein (38-99AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.
Gene References into Functions
  1. WRB gene contains a maternally imprinted differentially methylated region (DMR). The maternally inherited 5mCpG imprints at the WRB DMR are uncoupled from the parental allele expression of WRB and ten neighboring genes in twelve biosamples (brain, blood, fallopian tube, fetal large and small intestine, hESCs, large airway epithelial cells, thyroid, muscle, epidermal keratinocytes, ovary, skin, and testis). PMID: 27100087
  2. Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. PMID: 23041287
  3. The coiled-coil domain of WRB is the binding site for TRC40/Asna1. PMID: 21444755
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
WRB/GET1 family
Database Links

HGNC: 12790

OMIM: 602915

KEGG: hsa:7485

STRING: 9606.ENSP00000327716

UniGene: Hs.198308

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