XPNPEP3 Antibody

Datasheet

Code	CSB-PA026220GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q9NQH7

Target Names

XPNPEP3

Alternative Names

Aminopeptidase P3 antibody; APP3 antibody; NPHPL1 antibody; OTTHUMP00000199806 antibody; Probable Xaa Pro aminopeptidase 3 antibody; Probable Xaa-Pro aminopeptidase 3 antibody; X Pro aminopeptidase 3 antibody; X prolyl aminopeptidase (aminopeptidase P) 3 antibody; X-Pro aminopeptidase 3 antibody; XPNPEP3 antibody; XPP3_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human XPNPEP3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position.; Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.

Gene References into Functions

results therefore suggest XPNPEP3 to be a transcriptional target of Wnt/beta-catenin pathway with particular significance for CRC PMID: 29383790
Data suggest that human XPNPEP3, Ashbya gossypii Icp55, and Fusarium graminearum Icp55 exhibit structural and functional properties of genuine Xaa-Pro specific aminopeptidases; these enzymes appear to function in the previously observed mitochondrial role of Icp55 in processing of Nfs1 (mitochondrial cysteine desulfurase) substrate. [Icp55 = intermediate-cleavage metalloexopeptidases 55] PMID: 28476889
The findings reveal that APP3m is a new member of the TNF-TNFR2 signaling complex and characterize an APP3-mediated TNFR2 signal transduction mechanism that induces activation of JNK1 and JNK2. PMID: 25609706
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. PMID: 20179356

Involvement in disease

Nephronophthisis-like nephropathy 1 (NPHPL1)

Subcellular Location

[Isoform 1]: Mitochondrion. Cytoplasm.; [Isoform 2]: Cytoplasm.

Protein Families

Peptidase M24B family

Tissue Specificity

Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.

Database Links

HGNC: 28052

OMIM: 613159

KEGG: hsa:63929

STRING: 9606.ENSP00000349658

UniGene: Hs.529163

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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