ZFP57 Antibody, Biotin conjugated

Datasheet
Code CSB-PA865138LD01HU
Size US$299
Uniprot No. Q9NU63
Immunogen Recombinant Human Zinc finger protein 57 homolog protein (183-295AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698), ZFP57, C6orf40 ZNF698
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names ZFP57
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.
Involvement in disease Transient neonatal diabetes mellitus 1 (TNDM1)
Subcellular Location Nucleus
Protein Families Krueppel C2H2-type zinc-finger protein family, ZFP57 subfamily
Database Links

HGNC: 18791

OMIM: 601410

KEGG: hsa:346171

UniGene: Hs.156326

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