ZMIZ1 Antibody

1. In a two-stage genome-wide association study and subsequent replication study to identify genetic factors associated with primary dysmenorrhoea in Chinese women, analysis provided evidence of a significant (P<5 x 10(-8)) association at rs76518691 in the gene ZMIZ1 and at rs7523831 near NGF. PMID: 28447608
2. we have identified a molecular phenotype of MS defined by expression of the MS risk gene ZMIZ1 in blood, and by other genes, especially transcription factors. ZMIZ1 expression is affected by, and interacts with, the environmental risk factors EBV and Vitamin D. PMID: 28063629
3. rs1250569 (ZMIZ1) and rs10114470 (TL1A) are two novel loci that indicate susceptibility to Inflammatory Bowel Disease in Han-Chinese patients. PMID: 28456797
4. This case represents the first constitutional balanced translocation disrupting and fusing both MIZ-type containing and proline-rich 12 and provides clues for the potential function and effects of these in the central nervous system. PMID: 26163108
5. At the ZMIZ1 locus, we show that perturbation of ZMIZ1 expression in human islets and beta-cells influences exocytosis and insulin secretion, highlighting a novel role for ZMIZ1 in the maintenance of glucose homeostasis. PMID: 26624892
6. Targeting the NOTCH1-ZMIZ1 interaction might combat leukemic growth. PMID: 26522984
7. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. PMID: 26403403
8. ZMIZ1 is a susceptibility gene for vitiligo in Chinese population. PMID: 24667117
9. ZMIZ1 is overexpressed in a significant percentage of human breast, ovarian, and colon cancers in addition to human squamous cell carcinomas, suggesting that ZMIZ1 may play a broader role in epithelial cancers. PMID: 23426136
10. ZMIZ1 and activated NOTCH1 are coexpressed in a subset of human T-ALL patients and cell lines. PMID: 23161489
11. First line of evidence demonstrates a physiological role for endogenous Zimp10 in regulating Smad3/4-mediated transcription. PMID: 16777850
12. (RAI17) was found to be upregulated in WT-Add1 vs MUT-Add1 overexpressing cells, possibly representing a key molecule/axis for the functional Add1-induced effect PMID: 17512505
13. Expression of exogenous hZimp10 enhances the transcriptional activity of p53 and knockdown of endogenous hZimp10 reduces the transcriptional activity of p53. PMID: 17584785
14. provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis PMID: 17967885
15. Fusion of ZMIZ1 to ABL1 is associated with a B-cell acute lymphoblastic leukemia with a t(9;10)(q34;q22.3) translocation PMID: 18007576

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HGNC: 16493

OMIM: 607159

KEGG: hsa:57178

STRING: 9606.ENSP00000334474

UniGene: Hs.193118