ZMYND10 Antibody

Code CSB-PA026511ESR2HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western blot
    All lanes: ZMYND10 antibody at 8μg/ml
    Lane 1: A549 whole cell lysate
    Lane 2: Mouse kidney tissue
    Lane 3: Mouse skeletal muscle tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 51, 50 kDa
    Observed band size: 51 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026511ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA026511ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ZMYND10 Polyclonal antibody
Uniprot No. O75800
Target Names ZMYND10
Alternative Names ZMYND10 antibody; BLU antibody; LUCA12.4 antibody; Zinc finger MYND domain-containing protein 10 antibody; Protein BLu antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Zinc finger MYND domain-containing protein 10 protein (201-440AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : Western blot analysis

Sample type: cell

Review: Western blot analysis revealed that ZMYND10 mRNA expression was induced by miR-34a .

By Anonymous

Target Background

Function
Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
Gene References into Functions
  1. BLU suppressed tumor formation by strengthening the antitumor immunity. PMID: 28029652
  2. A novel frameshift mutation (c.367delC) in ZMYND10, unique for Slavic primary ciliary dyskinesia population (PCD), was found in homozygous state in two unrelated PCD patients. PMID: 26824761
  3. Data identified a novel functional BLU promoter that was regulated by Sp1. Furthermore, the hypermethylated -39 CpG in BLU proximal promoter directly reduced its binding with Sp1. PMID: 26043875
  4. Data show that the zinc finger MYND-type containing 10 protein BLU gene may be one of the key components of signaling networks controlling tumor microenvironment and angiogenesis. PMID: 25347745
  5. Mutations in ZMYND10 cause primary ciliary dyskinesia. PMID: 23891471
  6. Methylation of BLU could be a potential prognostic biomarker for advanced ovarian serous carcinoma PMID: 23329649
  7. Data indicate that BLU could suppress the growth of ovarian carcinoma cells through down-regulation of Bcl-2 protein. PMID: 23628417
  8. these data indicated that methylation of the BLU promoter region is an early event during hepatocellular carcinoma development. PMID: 22766745
  9. The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1. PMID: 22349239
  10. BLU may play a substantial role in the development and etiology of myelodysplastic syndrome. PMID: 22246278
  11. A significant correlation between BLU methylation and loss of expression of BLU was observed in gastric, colorectal and pancreatic cancers. PMID: 20394502
  12. These data suggest a significant role for epigenetic inactivation of BLU in the pathogenesis of common human cancers and that methylation inactivation of BLU occurs independent of RASSF1A in SCLC and neuroblastoma tumours. PMID: 12629521
  13. BLU may be one of the critical tumor suppressor genes on chromosome 3p21.3 involved in the development of nasopharyngeal carcinoma PMID: 12794757
  14. BLU, a candidate tumor suppressor gene, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. PMID: 15122337
  15. Smoking under age 18 is an independent risk for BLU hypermethylation, thus identifying a molecular alteration related to the epidemiologic effect of teenage smoking as a lung cancer risk. PMID: 15540210
  16. ninety-two percent of glioma tumor samples were methylated for RASSF1A, 30%-57% for BLU and 47% for MGMT, suggesting promoter methylation of these genes to be a common event in glioma tumorigenesis PMID: 18616639

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Involvement in disease Ciliary dyskinesia, primary, 22 (CILD22)
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Apical cell membrane. Dynein axonemal particle.
Protein Families ZMYND10 family
Database Links

HGNC: 19412

OMIM: 607070

KEGG: hsa:51364

STRING: 9606.ENSP00000231749

UniGene: Hs.526735

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