ZNF131 Antibody

Code CSB-PA026530LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026530LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA026530LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZNF131 Polyclonal antibody
Uniprot No.
Target Names
ZNF131
Alternative Names
ZNF131Zinc finger protein 131 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc finger protein 131 protein (80-379AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ZNF131 Antibody (Product code: CSB-PA026530LA01HU) is Non-conjugated. For ZNF131 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA026530LB01HU ZNF131 Antibody, HRP conjugated ELISA
FITC CSB-PA026530LC01HU ZNF131 Antibody, FITC conjugated
Biotin CSB-PA026530LD01HU ZNF131 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role during development and organogenesis as well as in the function of the adult central nervous system. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
Gene References into Functions
  1. Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability. PMID: 28596487
  2. identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY to a large number of active, H3K4me3 marked promoters. PMID: 26841866
  3. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131 PMID: 23404503
  4. these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor. PMID: 23159625
  5. SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation. PMID: 22467880
  6. The mechanism of Znf131 nuclear localization, is reported. PMID: 17306895
  7. Interaction between ZNF131 and ERalpha interrupts or prevents ERalpha binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1. PMID: 18847501

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Subcellular Location
Nucleus. Note=Sumoylation does not affect nuclear localization.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.
Database Links

HGNC: 12915

OMIM: 604073

KEGG: hsa:7690

UniGene: Hs.535804

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