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ZNF423 Antibody

Datasheet
Code CSB-PA026738OA01HU
Size US$166
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Image

  • IHC image of CSB-PA026738OA01HU diluted at 1:100 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA026738OA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZNF423 Polyclonal antibody
Uniprot No.
Q2M1K9
Target Names
ZNF423
Alternative Names
Early B cell factor associated zinc finger protein antibody; Ebfaz antibody; hOAZ antibody; JBTS19 antibody; KIAA0760 antibody; NPHP14 antibody; Nur12 antibody; OAZ antibody; OLF 1/EBF associated zinc finger antibody; OLF1/EBF associated zinc finger protein antibody; Olf1/EBF-associated zinc finger protein antibody; Roaz antibody; Smad and Olf interacting zinc finger protein antibody; Smad- and Olf-interacting zinc finger protein antibody; Zfp104 antibody; ZFP423 antibody; zinc finger protein 423, mouse, homolog of antibody; Zinc finger protein 423 antibody; ZN423_HUMAN antibody; ZNF423 antibody; ZNF423 zinc finger protein 423 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Zinc finger protein 423 protein (39-57AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ZNF423 Antibody (Product code: CSB-PA026738OA01HU) is Non-conjugated. For ZNF423 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA026738OB01HU ZNF423 Antibody, HRP conjugated ELISA
FITC CSB-PA026738OC01HU ZNF423 Antibody, FITC conjugated
Biotin CSB-PA026738OD01HU ZNF423 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Gene References into Functions
  1. We identified calmodulin-like protein 3 (CALML3) as a key sensor of this SNP and a coregulator of ERalpha, which contributes to differential gene transcription regulation in an estrogen and SERM-dependent fashion. Furthermore, using CRISPR/Cas9-engineered ZR75-1 breast cancer cells with different ZNF423 SNP genotypes, striking differences in cellular responses to SERMs and PARP inhibitors, alone or in combination PMID: 28821270
  2. We report that CTSO reduces the protein levels of BRCA1 and ZNF423 through cysteine proteinase-mediated degradation. We also have identified a series of transcription factors of BRCA1 that are regulated by CTSO at the protein level. PMID: 28968398
  3. two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias PMID: 26788497
  4. ZNF423 is a target for epigenetic deregulation and BMP2-dependent pathways in childhood B precursor acute lymphoblastic leukemia. Aberrant ZNF423 inhibits EBF-1 target genes, leads to a B cell maturation arrest in vivo and is associated with poor outcome of ETV6-RUNX1-negative acute lymphoblastic leukemia. PMID: 24081948
  5. OAZ gene expression was highly enriched in mesenchymal stem cells (MSCs) compared with peripheral blood leukocytes and was increased in patients with systemic lupus erythematosus (SLE) compared with control subjects. PMID: 25219468
  6. ZNF423 expression is associated with poor outcome of ETV6-RUNX1-negative B precursor acute lymphoblastic leukemia patients. PMID: 24081948
  7. These findings suggest that expression of UBR5-ZNF423 protein might contribute to the transformation of a subset of Nasopharyngeal carcinoma PMID: 23878065
  8. Elevated expression of OAZ transcripts in systemic lupus erythematosus PBLs were strongly correlated with disease activity. PMID: 20359360
  9. The expression level of OAZ mRNA in the bone marrow and peripheral blood of SLE patients was significantly increased than those observed in normal controls. PMID: 20017333
  10. Low ZNF423 expression is associated with neuroblastoma. PMID: 19345331

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Involvement in disease
Nephronophthisis 14 (NPHP14); Joubert syndrome 19 (JBTS19)
Subcellular Location
Nucleus.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala,
Database Links

HGNC: 16762

OMIM: 604557

KEGG: hsa:23090

STRING: 9606.ENSP00000262383

UniGene: Hs.443715

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