botA Antibody, HRP conjugated

Code CSB-PA320799LB01CLQ
Size US$299
Uniprot No. P0DPI0
Protocols ELISA Protocol
Immunogen Recombinant Clostridium botulinum Botulinum neurotoxin type A protein (1-436AA)
Raised in Rabbit
Species Reactivity Clostridium botulinum
Tested Applications ELISA
Relevance Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Botulinum neurotoxin type A (BoNT/A) (EC (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A light chain; Botulinum neurotoxin A heavy chain], botA, atx bna
Immunogen Species Clostridium botulinum
Research Area Others
Target Names botA
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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