cagA Antibody

Code CSB-PA345531YA01HUV
Size US$166
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Product Details

Full Product Name
Rabbit anti-Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) cagA Polyclonal antibody
Uniprot No.
Target Names
cagA
Alternative Names
cagA antibody; cag26 antibody; cai antibody; HP_0547Cytotoxicity-associated immunodominant antigen antibody; 120 kDa protein antibody; CAG pathogenicity island protein 26 antibody
Raised in
Rabbit
Species Reactivity
Helicobacter pylori
Immunogen
Recombinant Helicobacter pylori Cytotoxicity-associated immunodominant antigen protein (1-294AA)
Immunogen Species
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Conjugate
Non-conjugated

The cagA Antibody (Product code: CSB-PA345531YA01HUV) is Non-conjugated. For cagA Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA345531YB01HUV cagA Antibody, HRP conjugated ELISA
FITC CSB-PA345531YC01HUV cagA Antibody, FITC conjugated
Biotin CSB-PA345531YD01HUV cagA Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be necessary for the transcription, folding, export, or function of the cytotoxin.
Gene References into Functions
  1. The authors conclude that CagQ is a membrane protein in a type IV secretion system and is crucial for maintaining CagA expression and CagA-induced apoptotic effects. PMID: 29306012
  2. The vacuolating cytotoxin autotransporter (vacA) c1 genotype, but not cytotoxicity-associated immunodominant antigen (cagA) status, might be the first important bacterial biomarker for predicting the cardia adenocarcinoma risk. PMID: 29036792
  3. In this study, through quantitative analysis of the complex formation between CagA and PAR1b, the authors found that several CagA species have acquired elevated PAR1b-binding activity via duplication of the CagA multimerization motifs, while others have lost their PAR1b-binding activity. PMID: 27445265
  4. Helicobacter pylori expressing cagA and vacA genes is prevalent in dyspeptic Ghanaian patients. PMID: 28655347
  5. H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells. PMID: 28082808
  6. Data indicate that treatment of gastric epithelial cells with simvastatin reduced the level of cellular cholesterol and led to attenuation of translocation and phosphorylation of cytotoxin-associated gene A (CagA). PMID: 26730715
  7. Studies suggest that cytotoxin-associated gene A (CagA)-negative non-virulent strains of Helicobacter pylori may be a potential risk factor of pancreatic cancer. PMID: 26390415
  8. CagT plays an important role in the translocation of CagA into host epithelial cells. PMID: 23075784
  9. CagA upregulated CIP2A expression and this upregulation effect was dependent on Src and Ras/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways. PMID: 19959630
  10. In a stomach adenocarcinoma cell line, an increase in this protein correlated with the amount of the phosphorylated protein. PMID: 16278423
  11. These data demonstrate that VacA can downregulate CagA's effects on epithelial cells, a novel molecular mechanism showing how H. pylori can avoid excessive cellular damage. PMID: 19046339

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