pdeH Antibody, FITC conjugated

Datasheet
Code CSB-PA336327LC01ENV
Size US$299
Uniprot No. P37646
Immunogen Recombinant Escherichia coli Cyclic di-GMP phosphodiesterase PdeH protein (1-255AA)
Raised in Rabbit
Species Reactivity Escherichia coli
Tested Applications ELISA
Relevance Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of cyclic-di-GMP (c-di-GMP) (PubMed:18765794). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcEPdeH pair (module I) regulates the activity of the DgcMPdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD (PubMed:23708798). Effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR (PubMed:18765794).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Cyclic di-GMP phosphodiesterase PdeH, pdeH, yhjH
Immunogen Species Escherichia coli (strain K12)
Protocols ELISA Protocol
Research Area Others
Target Names pdeH
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function A bis-(3'-5') cyclic diguanylic acid (c-di-GMP) phosphodiesterase involved in regulating the levels of c-di-GMP that control cell motility (the flagella) and adhesion (adhesive curli fimbriae). The YhjH effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR, however curli expression is not regulated via YcgR. Forms a network with different diguanylate cyclases (DosC, YeaJ, YedQ, YegE have been identified) to regulate c-di-GMP levels. Flagellar activity is high at low c-di-GMP levels whereas curli fimbria are induced at high c-di-GMP levels. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.
Database Links

KEGG: ecj:JW3493

STRING: 316385.ECDH10B_3702

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