Recombinant Arabidopsis thaliana Ethylene-insensitive protein 2 (EIN2), partial

1. ENAP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C terminus. PMID: 27694846
2. In the presence of ethylene, EIN2 interacts with ENAP1, elevating the levels of H3K14Ac and H3K23Ac, promoting more EIN3 binding to the targets shared with ENAP1 and resulting in a rapid transcriptional regulation. PMID: 28874528
3. These results indicate that root responses to 6-pentyl-2H-pyran-2-one involve components of auxin transport and signaling and the ethylene-response modulator EIN2. PMID: 26568541
4. role in regulating organ growth by restricting cell expansion PMID: 26039475
5. Study reports another mechanism of EIN2-mediated ethylene signaling, whereby EIN2 imposes the translational repression of EBF1 and EBF2 mRNA and find that the EBF1/2 3' UTRs mediate EIN2-directed translational repression and identify multiple poly-uridylates (PolyU) motifs as functional cis elements of 3' UTRs. PMID: 26496607
6. Characterization of one of the targets of the translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response. PMID: 26496608
7. The data provide insight into an EIN2-mediated senescence signalling pathway that coordinates global gene expression during leaf senescence via a gene regulatory network. PMID: 24659488
8. the ore1 loss-of-function mutants were epistatic to nes1, suggesting the dominant role of ORE1 and the antagonistic role of NES1 during nitric oxide-induced cotyledon senescence in Arabidopsis. PMID: 24336389
9. EIN2 may be cleaved at alternative positions PMID: 23656878
10. Interactions between ECIP1 and EIN2 or ethylene receptors regulate ethylene response and stress response. PMID: 21631530
11. Data indicate that the expression and phosphorylation of ERF110 were regulated by ethylene via both Ethylene-Insensitive2-dependent and -independent pathways, which constitute a dual-and-opposing mechanism for ethylene in the regulation of bolting. PMID: 23188807
12. study demonstrated that EIN2 harboring a functional nuclear localization signal is subjected to a cleavage event, followed by transporting its carboxyl end (CEND) into the nucleus, where CEND acts to stabilize EIN3 and activate ethylene responses PMID: 23070300
13. reducing jasmonic acid levels, either mutationally or chemically, caused ein2 ethylene-insensitive mutants to become ethylene responsive. This effect was not seen with the ethylene-insensitive etr1-1 mutants that affect receptor function. PMID: 23219920
14. involved in nitric oxide signaling in the regulation of leaf senescence PMID: 22765302
15. These findings uncover a mechanism of subcellular communication whereby ethylene stimulates phosphorylation-dependent cleavage and nuclear movement of the EIN2-C' peptide, linking hormone perception and signaling components in the ER with nuclear-localized transcriptional regulators. PMID: 22936567
16. These data suggest a novel model on the integration of EIN2 in the ethylene signaling pathway. PMID: 21242723
17. AtMYB44 regulates induced expression of EIN2 in HrpN(Ea)-treated Arabidopsis plants. AtMYB44 protein localizes to nuclei and binds the EIN2 promoter; HrpN(Ea) treatment promotes AtMYB44 production, binding activity, and transcription of AtMYB44 and EIN2. PMID: 21117868
18. Data show that protein phosphorylation is a key mechanism to control the interaction of EIN2 and the receptors. PMID: 20591837
19. The etr1-3 and ein2-1 mutants exhibited less reductions in lateral root length and number than wild-type plants in response to high nitrate concentration. PMID: 19732351
20. EIN2 membrane protein is required for both the first and second phases of growth inhibition by ethylene in Arabidopsis seedling hypocotyls. PMID: 15466219
21. RCN1 and EIN2 modulate hypocotyl gravitropism and ethylene responses through independent pathways. PMID: 16798939
22. EIN2 is a cross-link node in ethylene, ABA and stress signaling pathways, and EIN2 is necessary to induce developmental arrest during seed germination, and seedling establishment, as well as subsequent vegetative growth PMID: 17533512
23. The results suggest that EIN2 gene mediates Pb(II) resistance, at least in part, through two distinct mechanisms, a GSH-dependent mechanism and a GSH-independent AtPDR12-mediated mechanism. PMID: 19153049
24. Overexpression of ETP1 or ETP2 disrupts EIN2 protein accumulation, and these plants manifest a strong ethylene-insensitive phenotype PMID: 19196655
25. ORE1 positively regulates aging-induced cell death; ORE1 expression is upregulated with leaf aging by EIN2 but negatively regulated by miR164; feed-forward pathway involving ORE1, miR164 & EIN2 provides regulation ensuring aging induces cell death PMID: 19229035
26. These results suggest that ethylene signals may be transduced by a phosphor-relay from receptors to transcriptional events via both ein2-dependent and -independent pathways. PMID: 19253305

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KEGG: ath:AT5G03280

STRING: 3702.AT5G03280.1

UniGene: At.1598